| The B cell receptor includes membrane &mu heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules. |
| Pathway Statistics |
| Molecules Involved | 152 |
| Physical Interactions | 172 |
| Enzyme Catalysis | 136 |
| Transport | 43 |
| Genes Transcriptionally Regulated | 435 |
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