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IL-5 Signaling Pathway  Accession number : NetPath_17
Interleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain which is shared between all members of this cytokine family. Binding of IL-5 to IL5RA recruits the beta chain to the complex, this then activates the JAK/STAT and Raf/MAPK signaling modules.
  Pathway Statistics
 Molecules Involved  57
 Physical Interactions  26
 Enzyme Catalysis  40
 Transport  6
 Genes Transcriptionally Regulated  176


  Molecules Involved in IL-5 signaling pathway (Total = 57)
 AKT1  ALOX5  APS  ATF2  BAX  BTK  CBL  CRKL  CSF2RB  CTNNB1  DNM2  ELK1  FOXO3A  GRB2  GSK3A
 GSK3B  HCK  HCLS1  IL2RB  IL5  IL5RA  JAK1  JAK2  JUN  KRAS  LYN  MAP2K2  MAPK1  MAPK14  MAPK3
 NFKB1  NFKBIA  PIK3CG  PIK3R1  PIK3R2  PLA2G4A  PRKCB1  PRKCD  PTK2B  PTPN11  PTPN6  RAF1  RAPGEF1  RPS6KA1  SDCBP
 SHC1  SHC2  SOCS1  SOX4  STAT1  STAT3  STAT5A  STAT5B  SYK  UNC119  VAV1  YWHAZ


  Reactions in IL-5 pathway (Total = 72)
   Physical Interactions
   Enzyme Catalysis
   Transport

  Genes Transcriptionally Regulated by IL-5 pathway (Total = 176)
   Upregulated genes
   Downregulated genes

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Last updated: Oct 23, 2009
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