| Interleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M. IL-6 signals through a ternary receptor complex consisting of IL-6 receptor alpha (IL6RA) and a homodimer of the signal transducing receptor gp130. IL-6 stimulates the association of IL6RA to gp130, which then activates the Jak/STAT, Ras/Raf/MAPK and PI 3-kinase signaling modules. |
| Pathway Statistics |
| Molecules Involved | 80 |
| Physical Interactions | 65 |
| Enzyme Catalysis | 58 |
| Transport | 7 |
| Genes Transcriptionally Regulated | 131 |
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