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IL-7 Signaling Pathway  Accession number : NetPath_19
Interleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common gamma chain (γc) that is shared between all members of this family. IL-7 mainly activates the JAK/STAT signaling module.
  Pathway Statistics
 Molecules Involved  16
 Physical Interactions  14
 Enzyme Catalysis  39
 Transport  2
 Genes Transcriptionally Regulated  71


  Molecules Involved in IL-7 signaling pathway (Total = 16)
 BCL2L11  FYN  IL2RG  IL7  IL7R  IRS1  IRS2  JAK1  JAK3  LYN  MCL1  PIK3R1  PTK2B  STAT3  STAT5A
 STAT5B


  Reactions in IL-7 pathway (Total = 55)
   Physical Interactions
   Enzyme Catalysis
   Transport

  Genes Transcriptionally Regulated by IL-7 pathway (Total = 71)
   Upregulated genes
   Downregulated genes

Download Pathway Download Transcriptionally Regulated Genes






Last updated: Oct 22, 2009

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