| The epidermal growth factor receptor (EGFR1) is a cell surface receptor that belongs to the EGFR/erbB family of receptor tyrosine kinases. Upon binding to its ligand Epidermal Growth Factor (EGF), this receptor can undergo homodimerization or heterodimerize with other members of the erbB family, ERBB2, ERBB3 or ERBB4, resulting in phosphorylation of the receptor subunits. In addition to EGF, the EGFR1 also binds to transforming growth factor alpha (TGF alpha), Amphiregulin, Betacellulin, Epiregulin and Heparin-binding EGF-like growth factor (HB-EGF). Ligand binding activates the Ras/Raf/MAPK signaling modules. |
| Pathway Statistics |
| Molecules Involved | 177 |
| Physical Interactions | 176 |
| Enzyme Catalysis | 249 |
| Transport | 50 |
| Genes Transcriptionally Regulated | 285 |
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