| The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. The receptor is composed of pairs of type I or II arranged in a heterotetrameric complex. Its ligand, TGF beta, has 3 members - TGFB1, TGFB2 and TGFB3, which can homodimerize or heterodimerize before binding to the receptors. Ligand binding activates the MAPK/SMAD signaling modules. |
| Pathway Statistics |
| Molecules Involved | 151 |
| Physical Interactions | 214 |
| Enzyme Catalysis | 57 |
| Transport | 8 |
| Genes Transcriptionally Regulated | 1564 |
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